Histomorphometric analysis of angiogenesis in oral submucous fibrosis and oral squamous cell carcinoma associated with oral submucous fibrosis

Background: Oral submucous fibrosis (OSMF), now worldwide acknowledged as the disease of “Southeast Asia and Indian subcontinent”, has utmost malignant transformation prevalence amongst oral precancerous disorders. Increased vascularity that is neoangiogenesis been observed in superficial connective tissue region pre-cancerous lesions showing dysplasia. This could be an initial occurrence carcinogenesis process. The aim this study will to analyse by examining immunoexpression CD105 OSMF, OSCC with OSMF cases. Methods: project comprise 30 normal mucosa samples (group I), clinicopathologically diagnosed cases II), on basis association surgically operated histopathologically associated III). Hematoxylin eosin stains used for routine staining procedures immunohistochemistry expression CD105. epithelial dysplasia (OED) categorized into two groups, low-risk (LRED) high-risk (HRED). micro vessel density (MVD), total microvessel area (TVA), mean (MVA) are within surrounding tumor sections immunostained antibody determined. ANOVA applied evaluation scores MVD, TVA, MVA groups II III. obtained score compared different parameters (TNM stage, lymph node metastasis, histopathological grades). Conclusions: We postulate progressively increased progression from LRED HRED further its invasive squamous cell carcinoma evident enhanced TVA MVA, which expressed immunoexpression. observation emphasize significance OSCC.